环卤克隆胺A - E：来自海洋海绵Haliclona sp.的二聚体、三聚体、四聚体、五聚体和六聚体3 - 烷基吡啶生物碱

Cyclohaliclonamines A-E: dimeric, trimeric, tetrameric, pentameric, and hexameric 3-alkyl pyridinium alkaloids from a marine sponge Haliclona sp.

作者信息

Teruya Toshiaki, Kobayashi Keiko, Suenaga Kiyotake, Kigoshi Hideo

机构信息

Department of Chemistry, University of Tsukuba, Tennoudai, Tsukuba 305-8571, Japan.

出版信息

J Nat Prod. 2006 Jan;69(1):135-7. doi: 10.1021/np050308+.

DOI:10.1021/np050308+

PMID:16441085

Abstract

A mixture of cyclohaliclonamines A-E (1-5), novel dimeric, trimeric, tetrameric, pentameric, and hexameric 3-alkylpyridinium alkaloids, was obtained from an Okinawan sponge Haliclona sp. Cyclohaliclonamines C-E are the first tetrameric, pentameric, and hexameric 3-alkylpyridinium alkaloids from natural sources. The structure determination of cyclohaliclonamines is discussed in detail.

摘要

从冲绳海绵Haliclona sp.中获得了环卤克隆胺A - E（1 - 5）的混合物，这是一类新型的二聚体、三聚体、四聚体、五聚体和六聚体3 - 烷基吡啶生物碱。环卤克隆胺C - E是首次从天然来源得到的四聚体、五聚体和六聚体3 - 烷基吡啶生物碱。文中详细讨论了环卤克隆胺的结构测定。