溶血巴斯德菌白细胞毒素在体外抑制有丝分裂原诱导的牛外周血单个核细胞增殖。
Pasteurella haemolytica leukotoxin inhibits mitogen-induced bovine peripheral blood mononuclear cell proliferation in vitro.
作者信息
Czuprynski C J, Ortiz-Carranza O
机构信息
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison 53706.
出版信息
Microb Pathog. 1992 Jun;12(6):459-63. doi: 10.1016/0882-4010(92)90009-d.
PMID:1522801
Abstract
In this study we demonstrate that partially purified Pasteurella haemolytica leukotoxin inhibits the proliferative response of bovine peripheral blood mononuclear cells (PBMC) to mitogens in vitro. Inhibition of PBMC proliferation did not appear to be due to cell death. Addition of a neutralizing anti-leukotoxin monoclonal antibody restored a normal proliferative response.
摘要
在本研究中，我们证明部分纯化的溶血巴斯德氏菌白细胞毒素在体外可抑制牛外周血单核细胞（PBMC）对有丝分裂原的增殖反应。PBMC增殖的抑制似乎并非由细胞死亡所致。添加中和性抗白细胞毒素单克隆抗体可恢复正常的增殖反应。
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