Bolkent S, Yanardağ R, Karabulut-Bulan O, Ozsoy-Saçan O
Department of Biology, Faculty of Science, Istanbul University, 34459 Vezneciler, Turkey.
Hum Exp Toxicol. 2004 May;23(5):257-64. doi: 10.1191/0960327104ht444oa.
Glibornuride is a sulphonylurea derivative used as an oral hypoglycaemic drug in diabetics. The aim of this study was to examine the histological, ultrastructural and biochemical effects of glibornuride in streptozotocin (STZ)-treated rats. The animals were rendered diabetic by intraperitoneal injection of 65 mg/kg STZ. Fourteen days later, glibornuride was given at 5 mg/kg by gavage, daily for 28 days, to one STZ-diabetic and one control group. In the STZ-diabetic group, remarkable degenerative changes were observed. On the other hand, in the STZ-diabetic group given glibornuride, the degenerative changes decreased. In the STZ-diabetic group, blood glucose levels, serum aspartate transaminase activity, and total lipid levels increased, whereas the blood glutathione levels decreased. In contrast, in the STZ-diabetic group given glibornuride blood glucose levels, serum aspartate transaminase activity and total lipid levels decreased and blood glutathione levels increased. Significant changes in total protein levels in the serum were not observed in any group. As a conclusion, we can say that glibornuride has a protective effect against the hepatotoxicity produced by STZ-diabetes.
格列本脲是一种磺酰脲类衍生物，用作糖尿病患者的口服降糖药。本研究的目的是研究格列本脲对链脲佐菌素（STZ）处理的大鼠的组织学、超微结构和生化影响。通过腹腔注射65mg/kg STZ使动物患糖尿病。14天后，对一个STZ糖尿病组和一个对照组每天经口灌胃给予5mg/kg格列本脲，持续28天。在STZ糖尿病组中，观察到明显的退行性变化。另一方面，在给予格列本脲的STZ糖尿病组中，退行性变化减少。在STZ糖尿病组中，血糖水平、血清天冬氨酸转氨酶活性和总脂质水平升高，而血液谷胱甘肽水平降低。相比之下，在给予格列本脲的STZ糖尿病组中，血糖水平、血清天冬氨酸转氨酶活性和总脂质水平降低，血液谷胱甘肽水平升高。在任何组中均未观察到血清总蛋白水平的显著变化。总之，我们可以说格列本脲对STZ糖尿病产生的肝毒性具有保护作用。
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