低价钛介导的连烯酯的环丙烷化反应

Low-valent titanium-mediated cyclopropanation of vinylogous esters.

作者信息

Masalov Nikolai, Feng Wei, Cha Jin Kun

机构信息

Department of Chemistry, Wayne State University, 5101 Cass Ave., Detroit, Michigan 48202, USA.

出版信息

Org Lett. 2004 Jul 8;6(14):2365-8. doi: 10.1021/ol0493047.

DOI:10.1021/ol0493047

PMID:15228280

Abstract

[reaction: see text] Inter- and intramolecular titanium-mediated cyclopropanation reactions of vinylogous esters are reported. Comparison between the Kulinkovich cyclopropanation of esters and vinylogous esters provides mechanistic insight regarding reaction variables such as reaction temperature, solvents, and a Lewis acid additive.

摘要

[反应：见正文] 报道了乙烯基酯的分子间和分子内钛介导的环丙烷化反应。酯和乙烯基酯的库林科维奇环丙烷化反应之间的比较为反应温度、溶剂和路易斯酸添加剂等反应变量提供了机理见解。