鬼灯檠地上部分的保肝黄酮醇苷

Hepatoprotective flavonol glycosides from the aerial parts of Rodgersia podophylla.

作者信息

Chin Young-Won, Lim Song Won, Kim Young Choong, Choi Sang Zin, Lee Kang Ro, Kim Jinwoong

机构信息

College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, San 56-1, Shinlim-dong, Kwanak-gu, Seoul 151-742, Korea.

出版信息

Planta Med. 2004 Jun;70(6):576-7. doi: 10.1055/s-2004-827163.

DOI:10.1055/s-2004-827163

PMID:15229810

Abstract

A new acylated flavonoid, quercetin 3- O-alpha- L-(5"- O-acetyl)-arabinofuranoside ( 1), along with six known flavonoids ( 2 - 7) were isolated from the aerial parts of Rodgersia podophylla. The new flavonoid 1 exhibited 50.1 % hepatoprotective activity at a concentration of 100 microM, and the three known compounds 3, 5 and 6 showed hepatoprotective activities at a concentration of 50 microM (45.7, 50.8 and 57.3 %, respectively) by using the primary cultures of rat hepatocytes injured by H (2)O (2).

摘要

从鬼灯檠的地上部分分离出一种新的酰化黄酮类化合物槲皮素3 - O -α - L -（5″ - O - 乙酰基） - 阿拉伯呋喃糖苷（1）以及六种已知的黄酮类化合物（2 - 7）。通过使用过氧化氢损伤的大鼠肝细胞原代培养物，新的黄酮类化合物1在浓度为100微摩尔时表现出50.1%的肝脏保护活性，三种已知化合物3、5和6在浓度为50微摩尔时表现出肝脏保护活性（分别为45.7%、50.8%和57.3%）。