来自芜菁变种地上部分的降异戊二烯类化合物和具有肝脏保护作用的黄酮苷。

Norisoprenoids and hepatoprotective flavone glycosides from the aerial parts of Beta vulgaris var. cicla.

作者信息

Kim Inkyum, Chin Young-Won, Lim Song Won, Kim Young Choong, Kim Jinwoong

机构信息

College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul 151-742, Korea.

出版信息

Arch Pharm Res. 2004 Jun;27(6):600-3. doi: 10.1007/BF02980156.

DOI:10.1007/BF02980156

PMID:15283459

Abstract

(+)-Dehydrovomifoliol (1), 3-hydroxy-5alpha,6alpha-epoxy-beta-ionone (2), vitexin 7-O-beta-D-glucopyranoside (3), and vitexin 2''-O-beta-D-glucopyranoside (4) were isolated as new constituents from the aerial parts of Beta vulgaris var. cicla. Compounds 3 and 4 demonstrated hepatoprotective activity with values of 65.8 and 56.1%, respectively, in primary cultured rat hepatocytes with CCl4-induced cell toxicity, compared to controls. This was comparable to that of silibinin (69.8 %) which was used as a positive control.

摘要

从甜菜变种莙荙菜的地上部分分离出了（+）-脱氢vomifoliol（1）、3-羟基-5α，6α-环氧-β-紫罗兰酮（2）、牡荆素7-O-β-D-吡喃葡萄糖苷（3）和牡荆素2''-O-β-D-吡喃葡萄糖苷（4）作为新成分。与对照组相比，化合物3和4在四氯化碳诱导细胞毒性的原代培养大鼠肝细胞中分别表现出65.8%和56.1%的保肝活性。这与用作阳性对照的水飞蓟宾（69.8%）相当。