Wolfsen H C, Hemminger L L, Geiger X J, Krishna M, Woodward T A
Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida 32224, USA.
Dis Esophagus. 2004;17(2):187-90. doi: 10.1111/j.1442-2050.2004.00400.x.
Esophageal squamous papillomatosis is a rare condition associated with human papilloma virus infection and has been complicated by the development of squamous cell carcinoma. Photodynamic therapy using porfimer sodium has been used for the treatment of esophageal cancer but has not been utilized in the treatment of esophageal squamous papillomatosis. We report here the first case of papillomatosis and obstructing squamous cell carcinoma of the esophagus palliated with porfimer sodium photodynamic therapy indicating successful photosensitizer uptake in papilloma-laden tissue. Extensive debulking of papilloma and tumor allowed esophageal recanalization and placement of a self-expanding metal stent for long-term dysphagia palliation. This unique case highlights the combined use of endoscopic techniques for optimal treatment results.
食管鳞状乳头瘤病是一种与人类乳头瘤病毒感染相关的罕见病症，且已因鳞状细胞癌的发展而复杂化。使用卟吩姆钠的光动力疗法已用于治疗食管癌，但尚未用于治疗食管鳞状乳头瘤病。我们在此报告首例采用卟吩姆钠光动力疗法缓解的食管乳头瘤病合并梗阻性鳞状细胞癌病例，表明在充满乳头瘤的组织中成功摄取了光敏剂。广泛切除乳头瘤和肿瘤使食管再通，并放置了自膨式金属支架以长期缓解吞咽困难。这一独特病例突出了内镜技术联合使用以获得最佳治疗效果。
