Karimi M, Peyvandi F, Siboni S, Ardeshiri R, Gringeri A, Mannucci P M
Hemostasis and Thrombosis Unit, Hematology Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Haemophilia. 2004 Jul;10(4):367-9. doi: 10.1111/j.1365-2516.2004.00927.x.
Prenatal diagnosis (PND) is an important issue in the comprehensive care of haemophiliacs. As a consequence of technological progress made in the field of PND, the early detection of an affected fetus provides the expectant couple with a chance to terminate pregnancy. This study was undertaken to assess the attitudes of two different haemophilic populations in Iran and Italy towards PND and termination of pregnancy. This study series included 59 Iranians (38 haemophilia A patients and 21 mothers) and 50 Italians (27 haemophilia A patients, 16 mothers and seven fathers). All the 109 participants received a questionnaire including demographic characteristics and evaluating the psychological effects stemming from PND and termination of pregnancy. Approximately 84.7% of the Iranians and 35.4% of the Italians were not familiar with the possibilities afforded by PND for haemophilia (P < 0.001). Termination of pregnancy appeared to be accepted by 58.2% of the Iranian and 16.7% of the Italian participants (P < 0.001). The greater rate of acceptability of abortion in Iranians may be due to differences in the quality of patient care in the two countries.
产前诊断（PND）在血友病患者的综合护理中是一个重要问题。由于产前诊断领域取得的技术进步，受影响胎儿的早期检测为准父母提供了终止妊娠的机会。本研究旨在评估伊朗和意大利两个不同血友病群体对产前诊断和终止妊娠的态度。该研究系列包括59名伊朗人（38名甲型血友病患者和21名母亲）和50名意大利人（27名甲型血友病患者、16名母亲和7名父亲）。所有109名参与者都收到了一份问卷，其中包括人口统计学特征，并评估产前诊断和终止妊娠所产生的心理影响。约84.7%的伊朗人和35.4%的意大利人不了解产前诊断对血友病的作用（P<0.001）。58.2%的伊朗参与者和16.7%的意大利参与者似乎接受终止妊娠（P<0.001）。伊朗人对堕胎的接受率较高可能是由于两国患者护理质量的差异。
