重度地中海贫血、血友病和唐氏综合征导致的终止妊娠：伊朗医生的观点。

Termination of pregnancy due to Thalassemia major, Hemophilia, and Down's syndrome: the views of Iranian physicians.

作者信息

Karimi Mehran, Bonyadi Mohammadmehdi, Galehdari Mohhamad reza, Zareifar Soheila

机构信息

Thrombosis and Hemostasis Unit, Hematology Research Center, Dept, of Pediatrics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

出版信息

BMC Med Ethics. 2008 Dec 23;9:19. doi: 10.1186/1472-6939-9-19.

DOI:10.1186/1472-6939-9-19

PMID:19105809

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2628659/

Abstract

BACKGROUND

Genetic disorders due to kindred marriages are common medical conditions in Iran; however, the legal aspects of abortion remain controversial. This study was undertaken to determine physicians' opinions regarding the termination of pregnancy for three genetic diseases: thalassemia major, hemophilia, and Down's syndrome.

METHODS

A questionnaire was administered to selected physicians by stratified random sampling to determine the following: age, gender, knowledge about prenatal diagnosis of diseases in high risk pregnancies, agreement with abortion, recommended gestational age for abortion, and, if opposed to abortion, the reason.

RESULTS

Of 323 physicians, who participated in the study, 91.3(295), 40.6(131), and 78.6%(254) were in agreement and 8.7(28), 59.4(192), and 21.4%(69) were opposed to abortion for thalassemia major, hemophilia, and Down's syndrome, respectively. Among 289 physicians opposed to abortion in respect of each of all three conditions, the following reasons were cited: religion, 18; emotional, 10; quality of care, 23; hope to find a new treatment option in the future, 103; miscellaneous reasons, 6; and a combination of these reasons, 129. Among 680 physicians in agreement with abortion in relation to all of the diseases, 4.6%(31) were agreed with abortion in less than 12 weeks gestation, 79.2%(538) in less than 16 weeks gestation, 5.6%(38) in less than 20 weeks gestation, 2.2%(15) in less than 24 weeks gestation, and 8.4%(58) were agreed with beyond the 24 weeks of gestational age.

CONCLUSION

The majority of physicians were in agreement with abortion for thalassemia major and Down's syndrome because of the overall prognosis, but opposed to abortion for hemophilia.

摘要

背景

近亲结婚导致的遗传疾病在伊朗是常见的医学状况；然而，堕胎的法律方面仍存在争议。本研究旨在确定医生对于三种遗传疾病（重型地中海贫血、血友病和唐氏综合征）终止妊娠的看法。

方法

通过分层随机抽样对选定的医生进行问卷调查，以确定以下内容：年龄、性别、对高危妊娠疾病产前诊断的了解、对堕胎的认同度、推荐的堕胎孕周，以及若反对堕胎，其原因。

结果

参与研究的323名医生中，分别有91.3%（295名）、40.6%（131名）和78.6%（254名）同意，8.7%（28名）、59.4%（192名）和21.4%（69名）反对因重型地中海贫血、血友病和唐氏综合征而堕胎。在针对所有这三种情况均反对堕胎的289名医生中，所提及的原因如下：宗教原因，18名；情感原因，10名；医疗质量原因，23名；希望未来找到新的治疗方案，103名；其他原因，6名；以及这些原因的组合，129名。在针对所有这些疾病均同意堕胎的680名医生中，4.6%（31名）同意在妊娠少于12周时堕胎，79.2%（538名）同意在少于16周时堕胎，5.6%（38名）同意在少于20周时堕胎，2.2%（15名）同意在少于24周时堕胎，8.4%（58名）同意在妊娠超过24周时堕胎。