局部用他扎罗汀化学预防可减少暴露于紫外线或电离辐射的Ptch1+/-小鼠的基底细胞癌数量和大小。

Topical tazarotene chemoprevention reduces Basal cell carcinoma number and size in Ptch1+/- mice exposed to ultraviolet or ionizing radiation.

作者信息

So Po-Lin, Lee Kenneth, Hebert Jennifer, Walker Patricia, Lu Ying, Hwang Jimmy, Kopelovich Levy, Athar Mohammed, Bickers David, Aszterbaum Michelle, Epstein Ervin H

机构信息

Department of Dermatology, University of California, San Francisco, California, USA.

出版信息

Cancer Res. 2004 Jul 1;64(13):4385-9. doi: 10.1158/0008-5472.CAN-03-1927.

DOI:10.1158/0008-5472.CAN-03-1927

PMID:15231643

Abstract

Oral retinoids can reduce basal cell carcinoma (BCC) incidence in genetically susceptible patients, and one topical retinoid, tazarotene, has been reported to cure some sporadic BCCs. Therefore, we have tested whether this agent would affect BCCs in Ptch1+/- mice in a controlled chemoprevention trial. We found that topical tazarotene dramatically inhibits the formation of BCCs induced with either UV or ionizing radiation. The ability of tazarotene to inhibit BCC formation in this mouse model provides encouragement for the use of tazarotene in skin cancer chemoprevention trials in humans.

摘要

口服维甲酸可降低基因易感性患者的基底细胞癌（BCC）发病率，据报道，一种外用维甲酸他扎罗汀可治愈一些散发性基底细胞癌。因此，我们在一项对照化学预防试验中测试了该药物是否会影响Ptch1+/-小鼠的基底细胞癌。我们发现，外用他扎罗汀可显著抑制紫外线或电离辐射诱导的基底细胞癌形成。他扎罗汀在该小鼠模型中抑制基底细胞癌形成的能力为其在人类皮肤癌化学预防试验中的应用提供了依据。