基底细胞癌——分子生物学与潜在的新疗法。
Basal cell carcinoma - molecular biology and potential new therapies.
机构信息
Karolinska Institutet, Center for Biosciences and Department of Biosciences and Nutrition, Novum, Huddinge, Sweden.
出版信息
J Clin Invest. 2012 Feb;122(2):455-63. doi: 10.1172/JCI58779. Epub 2012 Feb 1.
Abstract
Basal cell carcinoma (BCC) of the skin, the most common malignancy in individuals of mixed European descent, is increasing in incidence due to an aging population and sun exposure habits. The realization that aberrant activation of Hedgehog signaling is a pathognomonic feature of BCC development has opened the way for exciting progress toward understanding BCC biology and translation of this knowledge to the clinic. Genetic mouse models closely mimicking human BCCs have provided answers about the tumor cell of origin, and inhibition of Hedgehog signaling is emerging as a potentially useful targeted therapy for patients with advanced or multiple BCCs that have hitherto lacked effective treatment.
摘要
皮肤基底细胞癌（BCC）是混合欧洲血统人群中最常见的恶性肿瘤，由于人口老龄化和阳光暴露习惯，其发病率正在上升。人们认识到 Hedgehog 信号通路的异常激活是 BCC 发展的特征性特征，这为理解 BCC 生物学和将这些知识转化为临床应用开辟了令人兴奋的进展之路。与人类 BCC 非常相似的遗传小鼠模型为肿瘤起源细胞提供了答案，抑制 Hedgehog 信号通路正在成为一种潜在有用的靶向治疗方法，适用于迄今为止缺乏有效治疗方法的晚期或多发性 BCC 患者。
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Int J Dermatol. 2011 Jun;50(6):645-58. doi: 10.1111/j.1365-4632.2010.04826.x.
2
Targeting superficial or nodular Basal cell carcinoma with topically formulated small molecule inhibitor of smoothened.用靶向 smoothened 的局部小分子抑制剂治疗浅表性或结节性基底细胞癌。
Clin Cancer Res. 2011 May 15;17(10):3378-87. doi: 10.1158/1078-0432.CCR-10-3370. Epub 2011 May 10.
3
Nerve-derived sonic hedgehog defines a niche for hair follicle stem cells capable of becoming epidermal stem cells.神经源性 sonic hedgehog 为毛囊干细胞定义了一个能够成为表皮干细胞的小生境。
Cell Stem Cell. 2011 May 6;8(5):552-65. doi: 10.1016/j.stem.2011.02.021.
4
Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations.小鼠的基底细胞癌起源于毛囊干细胞和多个上皮祖细胞群体。
J Clin Invest. 2011 May;121(5):1768-81. doi: 10.1172/JCI46307. Epub 2011 Apr 25.
5
Topical treatment of Basal cell carcinomas in nevoid Basal cell carcinoma syndrome with a smoothened inhibitor.用 smoothened 抑制剂治疗结节性基底细胞癌综合征中的基底细胞癌的局部治疗。
J Invest Dermatol. 2011 Aug;131(8):1735-44. doi: 10.1038/jid.2011.48. Epub 2011 Mar 24.
6
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