Swithers-Mulvey S E, Mishu K R, Hall W G
Duke University, Department of Experimental Psychology, Durham, NC 27706.
Physiol Behav. 1992 Mar;51(3):639-42. doi: 10.1016/0031-9384(92)90189-9.
We have previously demonstrated a decremental, oral, experienced-based control of ingestion in rat pups that is potent, diet-specific, and long lasting. This control of ingestion is revealed in the decreases in mouthing responses of rat pups to repeated oral stimulation, a phenomenon that is well described as oral habituation. The present study examined the neural basis for oral habituation by examining the responses of decerebrate 10-day-old rat pups to repeated, brief infusions of a sucrose solution. Like neurologically intact pups, decerebrate pups showed distinct decreases in mouthing responses following a series of oral infusions. Thus, oral habituation is present in the hindbrain. Although intact pups demonstrated sensitization by showing increased responding to the first few stimulus presentations, decerebrates failed to show a sensitization to the stimulation. These results suggest that while the brainstem alone is sufficient for the expression of oral habituation, the forebrain also influences oral responsivity in intact animals.
我们之前已经证明，幼鼠存在一种基于经验的递减式口服摄入控制，这种控制作用强大、具有饮食特异性且持久。幼鼠对口部反复刺激的口部反应减少揭示了这种摄入控制，这一现象被很好地描述为口部习惯化。本研究通过检查去脑的10日龄幼鼠对蔗糖溶液反复短暂输注的反应，来探究口部习惯化的神经基础。与神经功能正常的幼鼠一样，去脑幼鼠在一系列口服输注后口部反应明显减少。因此，口部习惯化存在于后脑。虽然完整的幼鼠通过对最初几次刺激表现出反应增强而表现出敏感化，但去脑幼鼠对刺激并未表现出敏感化。这些结果表明，虽然仅脑干就足以表达口部习惯化，但前脑也会影响完整动物的口部反应性。
