皮肤型红斑狼疮的临床病程与预后

Clinical course and prognosis of cutaneous lupus erythematosus.

作者信息

Tebbe Beate

机构信息

Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Berlin, Germany.

出版信息

Clin Dermatol. 2004 Mar-Apr;22(2):121-4. doi: 10.1016/j.clindermatol.2003.12.018.

DOI:10.1016/j.clindermatol.2003.12.018

PMID:15234012

Abstract

Classical variants of specific cutaneous LE lesions are chronic discoid LE (CDLE) and subacute cutaneous LE (SCLE). CDLE and SCLE may appear at any age; however, the most common age of onset is between 20 and 40 years, with a female predominance of 3:1 in CDLE and 3-6:1 in SCLE. Nonspecific LE skin lesions such as generalized or acrolocalized vasculitis (4-30%), livedo reticularis (22-35%), and alopecia (38-78%) are frequently seen in patients with cutaneous LE. Other typical cutaneous LE subsets such as LE profundus/panniculitis, LE tumidus, urticaria vasculitis, hypertrophic LE, and bullous LE are rather rare variants. Butterfly rash and/or macular exanthema are characteristic skin lesions of systemic lupus erythematosus (SLE) rarely found in patients with cutaneous LE.

摘要

特定皮肤型红斑狼疮（LE）病变的经典类型为慢性盘状红斑狼疮（CDLE）和亚急性皮肤型红斑狼疮（SCLE）。CDLE和SCLE可在任何年龄出现；然而，最常见的发病年龄在20至40岁之间，CDLE中女性占比为3:1，SCLE中女性占比为3 - 6:1。非特异性皮肤型红斑狼疮皮肤病变，如全身性或肢端局限性血管炎（4 - 30%）、网状青斑（22 - 35%）和脱发（38 - 78%）在皮肤型红斑狼疮患者中很常见。其他典型的皮肤型红斑狼疮亚型，如深部红斑狼疮/脂膜炎、肿胀性红斑狼疮、荨麻疹性血管炎、肥厚性红斑狼疮和大疱性红斑狼疮则是较为罕见的类型。蝶形红斑和/或斑疹是系统性红斑狼疮（SLE）的特征性皮肤病变，在皮肤型红斑狼疮患者中很少见。