胃容纳和排空的同步评估：液体和固体餐食的研究
Simultaneous assessment of gastric accommodation and emptying: studies with liquid and solid meals.
作者信息
Simonian Hrair P, Maurer Alan H, Knight Linda C, Kantor Steve, Kontos Despina, Megalooikonomou Vasileios, Fisher Robert S, Parkman Henry P
机构信息
Gastroenterology Section, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
出版信息
J Nucl Med. 2004 Jul;45(7):1155-60.
UNLABELLED
The aim of this study was to develop a scintigraphic test to measure gastric emptying and accommodation simultaneously.
METHODS
Gastric emptying and accommodation were measured in healthy subjects. To determine gastric accommodation, the stomach was imaged with SPECT 20 min after intravenous administration of 185 MBq (5 mCi) (99m)Tc-pertechnetate. After ingestion of 11 MBq (300 micro Ci) (111)In-diethylenetriaminepentaacertic acid in a liquid nutrient drink or an (111)In-oxine-labeled egg sandwich, dual-isotope imaging assessed SPECT gastric dimensions and gastric emptying every 20 min up to 240 min. Gastric accommodation was calculated as the percentage change in planar (2-dimensional) gastric cross-sectional area (CSA) using a left anterior oblique planar projection and the percentage change in total SPECT gastric voxel counts (3-dimensional) compared with the baseline image.
RESULTS
With the liquid nutrient drink (9 subjects), maximal mean CSA (158% +/- 12% of baseline; P < 0.05) occurred 40 min after meal ingestion, when only 69% +/- 3% of the radiolabeled liquid nutrient drink remained in the stomach. At 120 min, mean CSA was 125% +/- 8% of baseline, but only 35% +/- 3% of the liquid nutrient drink remained in the stomach. Using SPECT to measure 3-dimensional volumes, maximal gastric volume occurred 20 min after meal ingestion (189% +/- 25% of baseline). With the solid egg meal (10 subjects), maximal total CSA (159% +/- 13% of baseline) occurred immediately after meal ingestion; total CSA remained significantly increased above baseline for the first 3 h after ingestion of the egg meal, despite only 12% +/- 4% gastric retention at 3 h. Using SPECT to measure 3-dimensional volumes, maximal gastric volume occurred immediately after the meal (184% +/- 19% of baseline).
CONCLUSION
This method permits simultaneous measurement of gastric emptying and accommodation. In healthy subjects, the gastric accommodation response is prolonged and persists despite nearly complete emptying of a liquid or solid meal.
未标注
本研究的目的是开发一种闪烁扫描试验，以同时测量胃排空和胃容纳功能。
方法
对健康受试者进行胃排空和胃容纳功能的测量。为测定胃容纳功能，静脉注射185 MBq（5 mCi）高锝（99m）Tc后20分钟，用单光子发射计算机断层扫描（SPECT）对胃进行成像。在摄入含11 MBq（300微居里）（111）铟 - 二乙三胺五乙酸的液体营养饮料或（111）铟 - 奥克辛标记的鸡蛋三明治后，采用双同位素成像，每20分钟评估一次SPECT胃尺寸和胃排空情况，直至240分钟。胃容纳功能通过使用左前斜平面投影计算平面（二维）胃横截面积（CSA）的变化百分比以及与基线图像相比SPECT胃体素计数（三维）的变化百分比来计算。
结果
对于液体营养饮料组（9名受试者），摄入餐后40分钟出现最大平均CSA（为基线的158%±12%；P<0.05），此时胃内仅残留69%±3%的放射性标记液体营养饮料。在120分钟时，平均CSA为基线的125%±8%，但胃内仅残留35%±3%的液体营养饮料。使用SPECT测量三维体积时，最大胃体积出现在摄入餐后20分钟（为基线的189%±25%）。对于固体鸡蛋餐组（10名受试者），摄入餐后立即出现最大总CSA（为基线的159%±13%）；尽管在摄入鸡蛋餐后3小时胃内仅保留12%±4%，但总CSA在摄入鸡蛋餐后的前3小时内仍显著高于基线水平。使用SPECT测量三维体积时，最大胃体积出现在餐后即刻（为基线的184%±19%）。
结论
该方法可同时测量胃排空和胃容纳功能。在健康受试者中，尽管液体或固体餐几乎完全排空，但胃容纳反应仍会延长并持续存在。
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