正常受试者和患者中固体和液体胃排空的同时13C/14C双同位素呼气试验测量：与闪烁扫描法的比较

Simultaneous 13C/14C dual isotope breath test measurement of gastric emptying of solid and liquid in normal subjects and patients: comparison with scintigraphy.

作者信息

Chew Chong G, Bartholomeusz Francis D L, Bellon Max, Chatterton Barry E

机构信息

Department of Nuclear Medicine and Bone Densitometry, Royal Adelaide Hospital, North Terrace, Adelaide, Australia.

出版信息

Nucl Med Rev Cent East Eur. 2003;6(1):29-33.

PMID:14600930

Abstract

BACKGROUND

To develop a simple method for simultaneous solid and liquid gastric emptying assessment using a dual isotope labelled breath test.

MATERIAL AND METHODS

13 patients were given 100 g ground beef labelled with 25 MBq (99m)Tc sulphur colloid and 74 KBq (14)C octanoic acid, and 150 ml 10% glucose drink labelled with 8 MBq (67)Ga citrate and 150 mg (13)C acetate. 10 normal volunteers were given the same test meals but labelled with (14)C and (13)C only. Breath was collected at baseline and regularly for 4 hours. The (14)CO(2) and (13)CO(2) activity was measured with liquid scintillation counting and mass spectroscopy. The times to maximum (14)CO(2) and (13)CO(2), were determined. Comparison was made between times to maximum (14)CO(2) with scintigraphic retention of (99m)Tc at 100 minutes and times to maximum (13)CO(2) with the scintigraphic half-clearance time of (67)Ga.

RESULTS

For the solid meal, the times to maximum (14)CO(2) were: 60-120 minutes in the 8 patients with normal gastric emptying of (99m)Tc; 75-145 minutes for the 10 healthy volunteers; 75-180 minutes for the remaining 5 patients with abnormal gastric emptying of (99m)Tc. There was a weak but significant correlation (r = 0.56, p < 0.025) between the time to maximum (14)CO(2) and gastric retention of (99m)Tc at 100 minutes. For the liquid meal, times to maximum (13)CO(2) were: 20-35 minutes for the 4 with normal gastric emptying of (67)Ga; 15-40 minutes for the 10 healthy volunteers; 20-75 minutes for the remaining 9 patients with abnormal gastric emptying of (67)Ga. There was a strong and significant correlation (r = 0.88, p < 0.005) between times to maximum (13)CO(2) and gastric half-clearance time of (67)Ga.

CONCLUSIONS

Breath tests utilising test meals labelled with *C isotopes are valid alternatives to scintigraphic studies using (99m)Tc and (67)Ga for the simultaneous assessment of gastric emptying of solids and liquids.

摘要

背景

开发一种使用双同位素标记呼气试验同时评估固体和液体胃排空的简单方法。

材料与方法

13名患者摄入含有25MBq（99m）锝硫胶体和74KBq（14）C辛酸标记的100克碎牛肉，以及含有8MBq（67）镓柠檬酸盐和150毫克（13）C醋酸盐标记的150毫升10%葡萄糖饮料。10名正常志愿者摄入仅用（14）C和（13）C标记的相同测试餐。在基线时及之后4小时定期收集呼气样本。用液体闪烁计数法和质谱法测量（14）CO₂和（13）CO₂活性。确定达到最大（14）CO₂和（13）CO₂的时间。比较达到最大（14）CO₂的时间与100分钟时（99m）锝的闪烁显像滞留情况，以及达到最大（13）CO₂的时间与（67）镓的闪烁显像半清除时间。

结果

对于固体餐，达到最大（14）CO₂的时间为：8名（99m）锝胃排空正常的患者为60 - 120分钟；10名健康志愿者为75 - 145分钟；其余5名（99m）锝胃排空异常的患者为75 - 180分钟。达到最大（14）CO₂的时间与100分钟时（99m）锝的胃滞留之间存在弱但显著的相关性（r = 0.56，p < 0.025）。对于液体餐，达到最大（13）CO₂的时间为：4名（67）镓胃排空正常的患者为20 - 35分钟；10名健康志愿者为15 - 40分钟；其余9名（67）镓胃排空异常的患者为20 - 75分钟。达到最大（13）CO₂的时间与（67）镓的胃半清除时间之间存在强且显著的相关性（r = 0.88，p < 0.005）。