Yilmaz Taner, Koçan Elif Gülin, Besler H Tanju
Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine, Hacettepe University, Hacettepe Ankara, Turkey.
Int J Pediatr Otorhinolaryngol. 2004 Aug;68(8):1053-8. doi: 10.1016/j.ijporl.2004.04.003.
To determine the possible role of oxidants and antioxidants in the pathogenesis of chronic tonsillitis (CT) and adenoid hypertrophy (AH) in children.
Randomized, prospective, controlled. The study group was made up of children with chronic tonsillitis and adenoid hypertrophy who are to undergo tonsillectomy and adenoidectomy. The control group was constructed with otherwise healthy children with normal ENT examination. The blood levels of antioxidants (retinol, beta-carotene, alpha-tocopherol, laycopene, ascorbic acid, superoxide dismutase, glutathione peroxidase, GSH) and peroxidation products (malondialdehyde) were determined before and 1 month after the operation in the study group and once only in the control group. These antioxidants and peroxidation products were also measured in the tonsil and adenoid tissue that were obtained during operation.
In the study group, the blood levels of antioxidants and oxidant before and after the operation were significantly different when compared to the control group (P < 0.05). In the study group, the blood antioxidant levels increased and oxidant level decreased significantly after the operation (P < 0.05). These levels after the operation never reached those of the control group.
Oxidants and antioxidants played a significant role in the pathogenesis of chronic tonsillitis and adenoid hypertrophy in children. These children are under significant oxidative stress. Tonsillectomy and adenoidectomy significantly decreased the oxidative stress in these patients, but could not normalize it completely. Further studies are necessary to evaluate their possible therapeutic role in preventing recurrent tonsillitis and treating postoperative patients to help normalize their blood levels of antioxidants.
确定氧化剂和抗氧化剂在儿童慢性扁桃体炎（CT）和腺样体肥大（AH）发病机制中的可能作用。
随机、前瞻性、对照研究。研究组由即将接受扁桃体切除术和腺样体切除术的慢性扁桃体炎和腺样体肥大患儿组成。对照组由耳鼻喉检查正常的健康儿童构成。在研究组中，于手术前及术后1个月测定血液中的抗氧化剂（视黄醇、β-胡萝卜素、α-生育酚、番茄红素、抗坏血酸、超氧化物歧化酶、谷胱甘肽过氧化物酶、谷胱甘肽）和过氧化产物（丙二醛）水平，对照组仅测定一次。还对手术中获取的扁桃体和腺样体组织中的这些抗氧化剂和过氧化产物进行了测量。
研究组手术前后血液中的抗氧化剂和氧化剂水平与对照组相比有显著差异（P<0.05）。研究组术后血液抗氧化剂水平显著升高，氧化剂水平显著降低（P<0.05）。术后这些水平从未达到对照组的水平。
氧化剂和抗氧化剂在儿童慢性扁桃体炎和腺样体肥大的发病机制中起重要作用。这些儿童处于显著的氧化应激状态。扁桃体切除术和腺样体切除术显著降低了这些患者的氧化应激，但未能使其完全恢复正常。有必要进一步研究评估它们在预防复发性扁桃体炎以及治疗术后患者以帮助使其血液抗氧化剂水平恢复正常方面的可能治疗作用。
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