Ekinci Adnan, Karataş Duran, Yetiş Abdurrahman, Demir Emre, Ozcan Muge
Department of Otorhinolaryngology Head and Neck Surgery, Hitit University, üctutlar mah.ahcılar 16.sokak. Ada apt.10/15, 19000, Corum, Turkey.
Department of Biostatistics, Faculty of Medicine, Hitit University, Corum, Turkey.
Eur Arch Otorhinolaryngol. 2017 Jul;274(7):2799-2802. doi: 10.1007/s00405-017-4546-3. Epub 2017 Apr 10.
The aim of this study is to compare the total antioxidant status (TAS), total oxidant status (TOS), and paraoxonase (PON1) serum levels in patients who have undergone septoplasty (NSD). Forty-six patients (mean age 33.7) aged between 18 and 50 years who were diagnosed with nasal septal deviation (NSD) were included in the study. The TAS, TOS, and PON1 levels were compared in the serum samples obtained 1 month before the septoplasty and 3 months after surgery. There was a significant increase in mean TAS after septoplasty (1.041 vs. 1.124 mmol/L, p = 0.011). The mean TOS decreased significantly after septoplasty (20.631 vs. 5.946 mmol/L, p = 0.011). The mean pre- and postoperative PON1 levels were similar (326.93 ± 215.22 vs. 275.20 ± 167.76 U/L, p = 0.253). Increased TAS and decreased TOS after septoplasty show that patients with NSD are under oxidative stress that is relieved following septoplasty.
本研究的目的是比较接受鼻中隔成形术（NSD）患者的总抗氧化状态（TAS）、总氧化状态（TOS）和对氧磷酶（PON1）血清水平。本研究纳入了46例年龄在18至50岁之间、被诊断为鼻中隔偏曲（NSD）的患者（平均年龄33.7岁）。在鼻中隔成形术前1个月和术后3个月采集的血清样本中比较TAS、TOS和PON1水平。鼻中隔成形术后平均TAS显著升高（1.041对1.124 mmol/L，p = 0.011）。鼻中隔成形术后平均TOS显著降低（20.631对5.946 mmol/L，p = 0.011）。术前和术后PON1的平均水平相似（326.93±215.22对275.20±167.76 U/L，p = 0.253）。鼻中隔成形术后TAS升高和TOS降低表明，NSD患者处于氧化应激状态，鼻中隔成形术后这种应激状态得到缓解。
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