商业制剂中表皮生长因子污染及完整人绒毛膜促性腺激素的浓度
Epidermal growth factor contamination and concentrations of intact human chorionic gonadotropin in commercial preparations.
作者信息
Yarram Sarah J, Jenkins Julian, Cole Lawrence A, Brown Nathan L, Sandy Jonathan R, Mansell Jason P
出版信息
Fertil Steril. 2004 Jul;82(1):232-3. doi: 10.1016/j.fertnstert.2003.11.051.
It is well-known that many urinary-derived human chorionic gonadotropin (hCG) preparations contain a variety of contaminating agents that may influence the efficacy and possible safety of their application. Herein, we report the finding of epidermal growth factor (EGF) contamination and high hCG beta core levels in two leading brands of hCG - findings that will promote the use of recombinant hCG instead of the cruder, urinary-derived formulations.
众所周知，许多尿源性人绒毛膜促性腺激素（hCG）制剂含有多种污染物，这些污染物可能会影响其应用的疗效和潜在安全性。在此，我们报告了在两种领先品牌的hCG中发现表皮生长因子（EGF）污染和高hCGβ核心水平——这些发现将促使人们使用重组hCG而非更粗糙的尿源性制剂。
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