早孕因子是人类绒毛膜促性腺激素商业制剂中的一种免疫抑制性污染物。
Early pregnancy factor is an immunosuppressive contaminant of commercial preparations of human chorionic gonadotrophin.
作者信息
Rolfe B E, Morton H, Clarke F M
出版信息
Clin Exp Immunol. 1983 Jan;51(1):45-52.
Abstract
Early pregnancy factor (EPF) is a pregnancy associated substance detected in human serum and urine throughout the first and second trimesters of pregnancy. It has also been detected in several commercial preparations of human chorionic gonadotrophin (hCG). The various molecular weight forms of EPF which occur in human pregnancy serum, urine and commercial hCG preparations have been partially characterized and found to be similar to each other but distinct from hCG. Further evidence is presented which suggests that it is EPF rather than hCG which is responsible for the immunosuppressive activity of some crude hCG preparations.
摘要
早孕因子（EPF）是一种在妊娠头三个月和第二个三个月期间可在人血清和尿液中检测到的与妊娠相关的物质。在几种人绒毛膜促性腺激素（hCG）的商业制剂中也检测到了它。已对人妊娠血清、尿液和商业hCG制剂中出现的各种分子量形式的EPF进行了部分表征，发现它们彼此相似，但与hCG不同。进一步的证据表明，某些粗制hCG制剂的免疫抑制活性是由EPF而非hCG引起的。
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