Foley Debra L, Eaves Lindon J, Wormley Brandon, Silberg Judy L, Maes Hermine H, Kuhn Jonathan, Riley Brien
Department of Human Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virgoinia Commonwaelth University, Richmond, 23298-0003, USA.
Arch Gen Psychiatry. 2004 Jul;61(7):738-44. doi: 10.1001/archpsyc.61.7.738.
Very little is known about how different sets of risk factors interact to influence risk for psychiatric disorder.
To replicate a recent report of a genotype-environment interaction that predicts risk for antisocial behavior in boys.
Characterizing risk for conduct disorder in boys in association with monoamine oxidase A genotype and exposure to familial adversity, defined by interparental violence, parental neglect, and inconsistent discipline.
A community-based sample of twin boys.
Five hundred fourteen male twins aged 8 to 17 years.
Conduct disorder.
There was a main effect of adversity but not of monoamine oxidase A on risk for conduct disorder. Low monoamine oxidase A activity increased risk for conduct disorder only in the presence of an adverse childhood environment. Neither a passive nor an evocative genotype-environment correlation accounted for the interaction.
This study replicates a recent report of a genotype-environment interaction that predicts individual variation in risk for antisocial behavior in boys.
对于不同风险因素组合如何相互作用以影响精神障碍风险，我们知之甚少。
复制最近一项关于基因 - 环境相互作用的报告，该相互作用可预测男孩反社会行为的风险。
结合单胺氧化酶A基因型以及由父母间暴力、父母忽视和不一致的管教所定义的家庭逆境，对男孩品行障碍风险进行特征描述。
基于社区的双胞胎男孩样本。
514名年龄在8至17岁的男性双胞胎。
品行障碍。
逆境对品行障碍风险有主效应，而单胺氧化酶A则没有。仅在童年不良环境存在时，低单胺氧化酶A活性才会增加品行障碍风险。被动或唤起性基因 - 环境相关性均不能解释这种相互作用。
本研究复制了最近一项关于基因 - 环境相互作用的报告，该相互作用可预测男孩反社会行为风险的个体差异。
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