Brain Susan D
Centre for Cardiovascular Biology and Medicine, King's College, Guy's Campus, London SE1 1UL.
Br J Pharmacol. 2004 Aug;142(7):1053-4. doi: 10.1038/sj.bjp.0705806. Epub 2004 Jul 5.
The neuropeptide calcitonin gene-related peptide (CGRP) is a potent vasodilator that is contained in and released from sensory nerves. CGRP has been implicated in migraine, and the nonpeptide CGRP antagonist BIBN4096BS has been shown to be effective in clinical trials in migraine. To date, it has been largely assumed that the CGRP antagonist is effective due to its ability to block vasodilator activity. Goadsby and co-workers present data that now suggest that CGRP antagonists may also block neuronal transmission in migraine.
神经肽降钙素基因相关肽(CGRP)是一种强效血管舒张剂,存在于感觉神经中并从感觉神经释放。CGRP与偏头痛有关,非肽类CGRP拮抗剂BIBN4096BS在偏头痛的临床试验中已显示出有效性。迄今为止,人们大多认为CGRP拮抗剂因其阻断血管舒张活性的能力而有效。戈德斯比及其同事提供的数据表明,CGRP拮抗剂在偏头痛中可能还会阻断神经传递。