[绵羊急性呼吸窘迫综合征招募容量定量方法的比较研究]

[A comparison study on quantitative methods for the recruited volume in sheep with acute respiratory distress syndrome].

作者信息

Xu Hong-yang, Qiu Hai-bo, Yang Yi, Zhou Shao-xia, Sun Hui-ming, Chen Yong-ming

机构信息

Department of Critical Care Medicine, Zhongda Hospital and School of Clinical Medicine, Southeast University, Nanjing 210009, Jiangsu, China.

出版信息

Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2004 Jul;16(7):413-6.

PMID:15238178

Abstract

OBJECTIVE

To compare equal pressure method with pressure-volume curve method to quantify the recruited volume.

METHODS

Acute respiratory distress syndrome sheep model was induced by intravenous infusion 3 microg/kg lipopolysaccharide (LPS). Recruited volume of three different levels of positive end-expiratory pressure (PEEP=5, 10, 15 cm H2O) were measured both by pressure-volume curve method and by equal pressure method.

RESULTS

The time needed to measure recruited volume by pressure-volume curve method was 5-6 minutes, which was longer than that of equal pressure method. Recruited volume measured by the two methods increased with PEEP. No significant difference was found between the recruited volume measured by equal pressure method and by equal pressure method at PEEP of 5 cm H2O, they were (25.79+/-20.48) ml vs. (63.26+/-54.57) ml (P>0.05), while recruited volume at PEEP of 10 cm H2O and 15 cm H2O measured by equal pressure method were lower than those measured by the pressure-volume curve method, they were (48.64+/-30.51)ml vs. (148.14+/-85.42)ml and (71.50+/-58.09)ml vs. (322.86+/-148.42)ml (all P<0.05) respectively.

CONCLUSION

Though equal pressure method is simple, it could not take the place of pressure-volume curve method to quantify recruited volume.

摘要

目的

比较等压法与压力-容积曲线法对肺复张容积的定量测定。

方法

经静脉注射3μg/kg脂多糖（LPS）建立急性呼吸窘迫综合征绵羊模型。采用压力-容积曲线法和等压法测定三种不同水平呼气末正压（PEEP = 5、10、15 cm H₂O）下的肺复张容积。

结果

压力-容积曲线法测定肺复张容积所需时间为5 - 6分钟，长于等压法。两种方法测得的肺复张容积均随PEEP增加而增大。在PEEP为5 cm H₂O时，等压法与压力-容积曲线法测得的肺复张容积差异无统计学意义，分别为（25.79±20.48）ml和（63.26±54.57）ml（P>0.05）；而在PEEP为10 cm H₂O和15 cm H₂O时，等压法测得的肺复张容积低于压力-容积曲线法，分别为（48.64±30.51）ml对（148.14±85.42）ml以及（71.50±58.09）ml对（322.86±148.42）ml（均P<0.05）。