Masmoudi Amine, Le Chevalier Thierry, Sabatier Laure, Soria Jean-Charles
Département de médecine, Institut Gustave-Roussy, 39 rue Camille-Desmoulins, 94805 Villejuif.
Bull Cancer. 2004 May;91 Spec No:S77-84.
Chemoprevention is the use of natural or synthetic compounds in order to reverse. suppress or prevent the carcinogenic process. Among the many pathways dysregulated during the carcinogenic process, cyclooxygenase-2 (Cox2) seems to be one of the most promising pathways to target in order to achieve chemopreventive and anticancer effects. Indeed, Cox2 overexpression contributes to the carcinogenic by at least 5 different mechanisms including transformation of procarcinogens on carcinogens, pro-inflammatory and immunomodulatory effect, resistance to apoptosis, angiogenesis and invasion progression... This review will focus on the rationale and the ongoing research areas related to chemopreventive approaches targeting Cox2.
化学预防是指使用天然或合成化合物来逆转、抑制或预防致癌过程。在致癌过程中失调的众多途径中，环氧合酶-2（Cox2）似乎是实现化学预防和抗癌效果最有前景的靶点途径之一。事实上，Cox2的过度表达通过至少5种不同机制促进致癌作用，包括将前致癌物转化为致癌物、促炎和免疫调节作用、抗细胞凋亡、血管生成和侵袭进展……本综述将重点关注针对Cox2的化学预防方法的基本原理和正在进行的研究领域。
