儿童感染性休克的管理
Management of septic shock in childhood.
作者信息
Sparrow Annie, Willis Frank
机构信息
Emergency Department, Princess Margaret Hospital for Children, Perth, Western Australia.
出版信息
Emerg Med Australas. 2004 Apr;16(2):125-34. doi: 10.1111/j.1742-6723.2004.00564.x.
OBJECTIVE
The object of this review is to discuss the recognition and treatment of septic shock in children based on principles of resuscitation, antibiotic use and recent therapeutic advances.
METHODS
A comprehensive literature search combining these
METHODS
on-line searches of Ovid, PubMed, and Medline; hand searches of 25 international journals; a trawl of 26 textbooks; searches of reference lists of pertinent articles; and scans of abstracts of recent international meetings. Various national and international units were contacted with regard to current research therapeutic strategies, both published and unpublished.
CONCLUSIONS
Septic shock remains a leading cause of morbidity and mortality in children. Early administration of empirical antibiotic therapy reduces mortality. The keystone of resuscitation is aggressive volume replacement. Adjunctive therapies to modulate the inflammatory response may further enhance outcome, but do not replace principles of resuscitation.
目的
本综述旨在基于复苏原则、抗生素使用及近期治疗进展，探讨儿童感染性休克的识别与治疗。
方法
进行全面的文献检索，包括对Ovid、PubMed和Medline的在线检索；对25种国际期刊的手工检索；查阅26本教科书；检索相关文章的参考文献列表；以及浏览近期国际会议的摘要。就已发表和未发表的当前研究治疗策略，联系了多个国家和国际单位。
结论
感染性休克仍是儿童发病和死亡的主要原因。早期给予经验性抗生素治疗可降低死亡率。复苏的关键是积极的容量复苏。调节炎症反应的辅助治疗可能进一步改善预后，但不能取代复苏原则。
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