Cogo P E
Minerva Pediatr. 2010 Jun;62(3 Suppl 1):137-9.
Mortality in pediatric cardiovascular failure is markedly improved with the advent of neonatal and pediatric intensive care and with the implementation of treatment guidelines. In 2002 the American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Shock reported mortality rates of 0%-5% in previously healthy and 10% in chronically ill children with septic shock associated with implementation of "best clinical practices". Early recognition of shock is the key to successful resuscitation in critically ill children. Often, shock results in or co-exists with myo-cardial dysfunction or acute lung injury. Recognition and appropriate management of these insults is crucial for successful outcomes. Resuscitation should be directed to restoration of tissue perfusion and normalization of cardiac and respiratory function. The underlying cause of shock should also be addressed urgently. The physiological response of individual children to shock resuscitation varies and is often unpredictable. Therefore, repeated assessments of vital parameters are needed for taking appropriate decisions. Global indices of tissue oxygen delivery help in targeting therapies more accurately. Isotonic fluids form the cornerstone of treatment and the amount required for resuscitation is based on etiologies and therapeutic response. After resuscitation has been initiated, targeted history and clinical evaluation must be performed to ascertain the cause of shock and management of co-morbidities should be implemented simultaneously. While the management of shock can be protocol based, the treatment needs to be individualized depending on the suspected etiology and therapeutic response particularly for children who suffer from congenital heart disease.
随着新生儿和儿科重症监护的出现以及治疗指南的实施,小儿心血管衰竭的死亡率显著降低。2002年,美国危重病医学会发布的《小儿和新生儿休克血流动力学支持临床实践参数》报告称,在实施“最佳临床实践”的情况下,先前健康的儿童脓毒症休克死亡率为0%-5%,慢性病儿童为10%。早期识别休克是危重病患儿成功复苏的关键。通常,休克会导致心肌功能障碍或急性肺损伤,或与之并存。识别并适当处理这些损伤对于取得成功的治疗结果至关重要。复苏应旨在恢复组织灌注以及使心脏和呼吸功能正常化。还应紧急处理休克的根本原因。个体儿童对休克复苏的生理反应各不相同,且往往不可预测。因此,需要反复评估生命体征参数以便做出适当决策。组织氧输送的整体指标有助于更准确地确定治疗目标。等渗液体是治疗的基石,复苏所需的液体量基于病因和治疗反应。开始复苏后,必须进行有针对性的病史询问和临床评估,以确定休克原因,并应同时处理合并症。虽然休克的管理可以基于方案进行,但治疗需要根据疑似病因和治疗反应进行个体化,特别是对于患有先天性心脏病的儿童。