哺乳期大鼠经阴道、迷走神经和乳腺刺激诱发的催产素释放的肾上腺素能和胆碱能控制（作者译）

[Adrenergic and cholinergic control of oxytocin release evoked by vaginal, vagal and mammary stimulation in lactating rats (author's transl)].

作者信息

Moos F, Richard P

出版信息

J Physiol (Paris). 1975 Nov;70(3):315-32.

PMID:1524

Abstract

The amounts of oxytocin released during Ferguson and vago-pituitary reflexes are estimated by measurements of intramammary pressure. For the milk-ejection reflex, the gain in weight of the young over a period of 30 minutes is taken as an indirect index of the release of oxytocin. 2. Antagonists of specific cholinoceptors and adrenoceptors were injected into the third ventricle in order to delineate the role of the mediators and receptors in the control of oxytocin release. 3. The results suggest that three reflexes have a specific chemical transmission since: a) The Ferguson reflex is inhibited by the drugs that only block alpha and beta adrenoceptors. b) The vago-pituitary reflex is inhibited by the drugs that block alpha and beta adrenoceptors and muscarinic cholinoceptors. c) The milk-ejection reflex is inhibited by the drugs that block alpha adrenoceptors and muscarinic and nicotinic cholinoceptors.

摘要

通过测量乳房内压力来估计弗格森反射和迷走-垂体反射期间释放的催产素量。对于喷乳反射，幼崽在30分钟内体重的增加被用作催产素释放的间接指标。2. 将特定胆碱能受体和肾上腺素能受体的拮抗剂注入第三脑室，以阐明介质和受体在催产素释放控制中的作用。3. 结果表明，三种反射具有特定的化学传递，因为：a）弗格森反射被仅阻断α和β肾上腺素能受体的药物所抑制。b）迷走-垂体反射被阻断α和β肾上腺素能受体以及毒蕈碱胆碱能受体的药物所抑制。c）喷乳反射被阻断α肾上腺素能受体以及毒蕈碱和烟碱胆碱能受体的药物所抑制。