Moos F, Richard P
Neuroendocrinology. 1979;28(2):138-44. doi: 10.1159/000122854.
(1) Haloperidol, a dopaminergic antagonist was injected i.p. or into the 3rd ventricle (i.c.v.) of lactating rats to determine whether or not a dopaminergic component was involved in the reflex release of oxytocin (OT) induced by (a) vaginal dilatation (Ferguson reflex), (b) vagal stimulation (vago-pituitary reflex), (c) suckling (milk-ejection reflex). Moreover, we examined the effect of a dopaminergic agonist, apomorphine, on the milk-ejection (ME) reflex. (2) I.c.v. injection of 20 microgram haloperidol inhibited the vaginal and vagal reflexes. The inhibition of the ME reflex produced by 2, 5 or 8 mg/kg i.p. or by 20 and 40 microgram i.c.v. haloperidol was dose-dependent. Apomorphine (10 mg/kg i.p.) had no effect. (3) The results suggest that a dopaminergic component must be involved in OT release whatever the peripheral stimulus.
(1) 将多巴胺能拮抗剂氟哌啶醇腹腔注射或注入泌乳大鼠的第三脑室（脑室内），以确定多巴胺能成分是否参与由以下因素诱导的催产素（OT）反射性释放：(a) 阴道扩张（弗格森反射）、(b) 迷走神经刺激（迷走-垂体反射）、(c) 哺乳（射乳反射）。此外，我们研究了多巴胺能激动剂阿扑吗啡对射乳（ME）反射的影响。(2) 脑室内注射20微克氟哌啶醇可抑制阴道和迷走神经反射。腹腔注射2、5或8毫克/千克或脑室内注射20和40微克氟哌啶醇对ME反射的抑制作用呈剂量依赖性。阿扑吗啡（腹腔注射10毫克/千克）无作用。(3) 结果表明，无论外周刺激如何，多巴胺能成分必定参与OT释放。
