Nulman I, Rovet J, Kennedy D, Wasson C, Gladstone J, Fried S, Koren G
The Motherisk Program, Division of Clinical Pharmacology/Toxicology, Departments of Pediatrics and Psychology, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8.
Arch Womens Ment Health. 2004 Jul;7(3):173-81. doi: 10.1007/s00737-004-0055-7. Epub 2004 Jun 22.
Effects of binge ethanol consumption during early gestation on child neurodevelopment have not been elucidated. To study whether binge drinking affects cognitive abilities and behavior of exposed children, a prospective observational study comparing 51 children exposed to binge drinking during the first trimester of pregnancy to 51 children not exposed to any teratogens was conducted. The children's physical development, intelligence, language abilities and behavior were assessed. Temperament test results showed that children exposed in utero to maternal binge drinking displayed a greater degree of disinhibited behavior and that this behavior was associated with early drinking variables. Although binge alcohol drinking by non-alcohol-dependent women during the first trimester of pregnancy does not appear to affect intelligence or cognitive and language development of young children, binge drinking in pregnancy does increase the likelihood of certain behavioral characteristics that might predispose these children to later behavioral dysfunction.
妊娠早期暴饮乙醇对儿童神经发育的影响尚未阐明。为了研究暴饮是否会影响受暴露儿童的认知能力和行为，进行了一项前瞻性观察研究，将51名在妊娠头三个月暴露于暴饮的儿童与51名未暴露于任何致畸物的儿童进行比较。评估了儿童的身体发育、智力、语言能力和行为。气质测试结果表明，子宫内暴露于母亲暴饮的儿童表现出更高程度的行为抑制解除，并且这种行为与早期饮酒变量有关。尽管非酒精依赖型女性在妊娠头三个月暴饮乙醇似乎不会影响幼儿的智力或认知及语言发育，但孕期暴饮确实会增加某些行为特征的可能性，这些特征可能使这些儿童日后易出现行为功能障碍。
