来自加蓬的一只圈养宠物白领白眉猴体内发现的一种新型猴免疫缺陷病毒1型。

A New STLV-1 in a household pet Cercopithecus nictitans from Gabon.

作者信息

Makuwa Maria, Souquiere Sandrine, Telfer Paul, Mouinga-Ondeme Augustin, Bourry Olivier, Roques Pierre

机构信息

Laboratoire de Virologie, UGENET, CDP, Centre International de Recherches Médicales, Franceville, Gabon.

出版信息

AIDS Res Hum Retroviruses. 2004 Jun;20(6):679-83. doi: 10.1089/0889222041217365.

DOI:10.1089/0889222041217365

PMID:15242546

Abstract

A recent serological survey of wild-born captive monkeys from Gabon, Central Africa, revealed that 1 of 20 Cercopithecus nictitans tested was infected with a new simian T cell lymphotropic virus type 1 (STLV-1). We investigated the molecular relationship between the STLV-1 strain present in this C. nictitans (CN01) and the other available HTLV/STLV strains. Phylogenetic analysis of the env (gp46 and gp21) region showed that the new STLV(nict) clusters with the HTLV-1/STLV-1 group and not with the other nictitans STLVs belonging to the STLV-3 group. Moreover, our new STLV(nict) is closely related to the molecular subtype D, which presently includes five HTLV-1 and three mandrill STLV-1 strains from Gabon and two from Cameroon. These data show that C. nictitans may be the natural carrier of two different molecular types of STLV, one related to STLV-3 and the other possibly one of the simian STLV type 1 counterparts of HTLV-1 subtype D.

摘要

最近对来自中非加蓬野生出生的圈养猴子进行的血清学调查显示，在20只接受检测的白颈白眉猴中，有1只感染了一种新的1型猿猴嗜T细胞病毒（STLV-1）。我们研究了这只白颈白眉猴（CN01）中存在的STLV-1毒株与其他可用的HTLV/STLV毒株之间的分子关系。对env（gp46和gp21）区域的系统发育分析表明，新的STLV（nict）与HTLV-1/STLV-1组聚类，而不与属于STLV-3组的其他白颈白眉猴STLV聚类。此外，我们的新STLV（nict）与分子亚型D密切相关，目前分子亚型D包括来自加蓬的5株HTLV-1和3株山魈STLV-1毒株以及来自喀麦隆的2株。这些数据表明，白颈白眉猴可能是两种不同分子类型STLV的天然宿主，一种与STLV-3相关，另一种可能是HTLV-1亚型D的猿猴STLV-1对应物之一。