Solensky Roland
Division of Allergy & Immunology, The Corvallis Clinic, 3680 NW Samaritan Drive, Corvallis, OR 97330, USA.
Immunol Allergy Clin North Am. 2004 Aug;24(3):425-43, vi. doi: 10.1016/j.iac.2004.03.008.
Although most patients who report a history of drug allergy are not truly allergic, this article focuses on those individuals with confirmed drug hypersensitivity. Desensitization is an immunologic method that allows allergic patients to receive the sensitizing drug safely. Classically, the procedure is applied in IgE-mediated reactions, but its use has been extended to other drug reactions. The most common clinical scenarios wherein desensitization may be needed are reviewed. The discussion includes rapid desensitization of patients with IgE-mediated allergies to penicillin and other classes of antibiotics, and sulfonamide desensitization of HIV-positive patients.
尽管大多数自述有药物过敏史的患者并非真正过敏,但本文重点关注那些确诊为药物超敏反应的个体。脱敏是一种免疫学方法,可使过敏患者安全地接受致敏药物。传统上,该方法应用于IgE介导的反应,但现在其应用范围已扩展到其他药物反应。本文综述了可能需要进行脱敏治疗的最常见临床情况。讨论内容包括对青霉素和其他类抗生素发生IgE介导过敏反应患者的快速脱敏,以及HIV阳性患者的磺胺类药物脱敏。