Gruchalla R S
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-8859, USA.
Clin Exp Allergy. 1998 Sep;28 Suppl 4:63-4.
Evidence is accumulating that supports a role for acute desensitization for IgE-mediated drug allergy in those patients for whom no alternative drug exists. While most of the studies have been performed in penicillin-allergic patients, this procedure has been used safely in patients with IgE sensitivity to other agents. In addition, it has been shown that modified desensitization protocols may be effective in the prevention of other immune-mediated drug reactions, as well. Thus, while much research remains to be done in this area, drug desensitization will continue to be a powerful tool in the management of drug allergy.
越来越多的证据支持，对于那些没有替代药物的患者，急性脱敏在IgE介导的药物过敏中发挥作用。虽然大多数研究是在青霉素过敏患者中进行的，但该程序已在对其他药物有IgE敏感性的患者中安全使用。此外，已表明改良的脱敏方案在预防其他免疫介导的药物反应方面也可能有效。因此，虽然该领域仍有许多研究有待开展，但药物脱敏将继续成为药物过敏管理中的有力工具。
