Ullmann Andrew J, Karthaus Meinolf, Cornely Oliver A
III. Medizinische Klinik und Poliklinik, Klinikum der Johannes Gutenberg-Universität, Mainz, Deutschland.
Wien Med Wochenschr. 2004 May;154(9-10):218-25. doi: 10.1007/s10354-004-0068-x.
Vaccinations are safe and effective in immunocompromised patients. Apparently most vaccines in this patient population are underutilized. General vaccination recommendations are expressed for influenza, diphtheria and tetanus. Pneumococcal, meningococcal und Haemophilus influenzae B immunizations are specially indicated for patients with or developing B-cell-deficiency. Live attenuated vaccines are usually contraindicated. The efficacy of the immunization and its indication can be additionally measured by antibody response, which is usually decreased compared to healthy subjects. Immunocompromised hosts with cancer will benefit from consistent immunization practices. Further clinical trials are urgently warranted.
疫苗接种在免疫功能低下的患者中是安全有效的。显然,这一患者群体中的大多数疫苗未得到充分利用。针对流感、白喉和破伤风给出了一般性的疫苗接种建议。肺炎球菌、脑膜炎球菌和B型流感嗜血杆菌疫苗接种特别适用于患有或正在发展为B细胞缺陷的患者。减毒活疫苗通常是禁忌的。免疫接种的效果及其适应证可以通过抗体反应来进一步衡量,与健康受试者相比,抗体反应通常会降低。患有癌症的免疫功能低下宿主将从持续的免疫接种实践中受益。迫切需要进一步的临床试验。