基于星形聚（ε-己内酯-co-D,L-丙交酯）的热固性可生物降解弹性体的合成与表征

Synthesis and characterization of thermoset biodegradable elastomers based on star-poly(epsilon-caprolactone-co-D,L-lactide).

作者信息

Amsden B, Wang S, Wyss U

机构信息

Department of Chemical Engineering, Queen's University, Kingston, Ontario, Canada K7L 3N6.

出版信息

Biomacromolecules. 2004 Jul-Aug;5(4):1399-404. doi: 10.1021/bm034538j.

DOI:10.1021/bm034538j

PMID:15244457

Abstract

Biodegradable elastomers represent a useful class of biomaterials. In this paper, we synthesize thermoset elastomers by utilizing the living nature of ring-opening polymerization of a star copolymer of D,L-lactide and epsilon-caprolactone initiated with glycerol and catalyzed by stannous 2-ethylhexanoate. The star copolymers were synthesized of varying molecular weight and monomer composition and cross-linked by compression molding using a dilactone, bis(epsilon-caprolactone-4-yl)propane dissolved in epsilon-caprolactone monomer. The elastomers were then characterized by differential scanning calorimetry and uniaxial tensile testing and their physical properties related to the nature of the star copolymer prepolymers. The results demonstrate a means of predictably altering the elastomer physical properties by adjusting the star copolymer prepolymer initial molecular weight and monomer ratio.

摘要

可生物降解弹性体是一类有用的生物材料。在本文中，我们利用甘油引发、2-乙基己酸亚锡催化的D，L-丙交酯和ε-己内酯星形共聚物的开环聚合反应的活性，合成了热固性弹性体。合成了不同分子量和单体组成的星形共聚物，并使用溶解在ε-己内酯单体中的双内酯双（ε-己内酯-4-基）丙烷通过压缩模塑进行交联。然后通过差示扫描量热法和单轴拉伸试验对弹性体进行表征，并将其物理性能与星形共聚物预聚物的性质相关联。结果表明，通过调节星形共聚物预聚物的初始分子量和单体比例，可以可预测地改变弹性体的物理性能。