光交联星形聚（ε-己内酯-co-D，L-丙交酯）弹性体的体内降解行为

In vivo degradation behavior of photo-cross-linked star-poly(epsilon-caprolactone-co-D,L-lactide) elastomers.

作者信息

Amsden Brian G, Tse M Yat, Turner Norma D, Knight Darryl K, Pang Stephen C

机构信息

Departments of Chemical Engineering and of Cell Biology and Anatomy, Queen's University, Kingston, Ontario, Canada K7L 3N6.

出版信息

Biomacromolecules. 2006 Jan;7(1):365-72. doi: 10.1021/bm050731x.

DOI:10.1021/bm050731x

PMID:16398537

Abstract

We have recently reported on the preparation of biodegradable elastomers through photo-cross-linking acrylated star-poly(epsilon-caprolactone-co-D,L-lactide). In this paper we assess the change in their physical properties during in vivo degradation in rats after subcutaneous implantation over a 12 week period. These parameter changes were compared to those observed in vitro. Two different cross-link densities were examined, representing the range from a high Young's modulus to a low Young modulus. Elastomers having a high cross-link density exhibited degradation behavior consistent with a surface erosion mechanism, and degraded at the same rate in vivo as observed in vitro. Young's modulus and the stress at break of these elastomers decreased linearly with the degradation time, while the strain at break decreased slowly. Elastomers having a low cross-link density exhibited a degradation mechanism consistent with bulk erosion. Young's modulus and the stress at break of these elastomers decreased slowly initially, followed by a marked increase in mechanical strength loss after 4 weeks. The elastomers were well tolerated by the rats over the 12 week period in vivo.

摘要

我们最近报道了通过光交联丙烯酸化星形聚（ε-己内酯-co-D，L-丙交酯）制备可生物降解弹性体的方法。在本文中，我们评估了在大鼠皮下植入12周后体内降解过程中它们物理性质的变化。将这些参数变化与体外观察到的变化进行比较。研究了两种不同的交联密度，代表了从高杨氏模量到低杨氏模量的范围。具有高交联密度的弹性体表现出与表面侵蚀机制一致的降解行为，并且在体内的降解速率与体外观察到的相同。这些弹性体的杨氏模量和断裂应力随降解时间呈线性下降，而断裂应变下降缓慢。具有低交联密度的弹性体表现出与本体侵蚀一致的降解机制。这些弹性体的杨氏模量和断裂应力最初下降缓慢，4周后机械强度损失显著增加。在体内12周期间，大鼠对这些弹性体耐受性良好。