Dobbelaere Dirk A E, Küenzi Peter
Division of Molecular Pathology, Institute of Animal Pathology, University of Bern, Länggassstrasse 122, CH-3012 Bern, Switzerland.
Curr Opin Immunol. 2004 Aug;16(4):524-30. doi: 10.1016/j.coi.2004.05.009.
Theileria parasites infect and transform cells of the ruminant immune system. Continuous proliferation and survival of Theileria-transformed cells involves the well-orchestrated activation of several host-cell signalling pathways. Constitutive NF-kappa B (nuclear factor kappa B) activation is accomplished by recruiting the IKK (I kappa B kinase) complex, a central regulator of NF-kappa B pathways, to the surface of the transforming schizont, where it becomes permanently activated. Constitutive activation of the PI-3K-PKB [phosphoinositide 3-kinase-(Akt) protein kinase B] pathway is likely to be indirect and is essential for continuous proliferation. Theileria-transformed T cells express a range of anti-apoptotic proteins that can be expected to provide protection against apoptosis induced by death receptors, as well as cellular control mechanisms that are mobilised to eliminate cells that entered a cycle of uncontrolled proliferation.
泰勒虫寄生虫感染并转化反刍动物免疫系统的细胞。泰勒虫转化细胞的持续增殖和存活涉及多个宿主细胞信号通路的精心激活。组成型核因子κB（NF-κB）的激活是通过将IKK（IκB激酶）复合物（NF-κB通路的核心调节因子）募集到转化裂殖体的表面来实现的，在那里它会被永久激活。PI-3K-PKB[磷脂酰肌醇3-激酶-（Akt）蛋白激酶B]通路的组成型激活可能是间接的，并且对于持续增殖至关重要。泰勒虫转化的T细胞表达一系列抗凋亡蛋白，预计这些蛋白可以提供针对死亡受体诱导的凋亡的保护，以及动员起来消除进入不受控制增殖周期的细胞的细胞控制机制。
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