与其他顶复门寄生虫相比，对泰勒虫（Theileria velifera）线粒体基因组结构和系统发育位置的见解。
Insights into the mitochondrial genome structure and phylogenetic placement of Theileria velifera in comparison to other apicomplexan parasites.
作者信息
Yang Xing, Tang Shaobo, Du Chaobo, Chen Yuqing, Luo Zhi, Li Miao, Liu Shuang, Duan Mingna, Jiang Dandan, Shen Yujuan, Zhang Quanfu, Du Chunhong
机构信息
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Key Laboratory of Parasite and Vector Biology, Collaborating Centre for Tropical Diseases, National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention, Chinese Center for Tropical Diseases Research, National Health Commission of the People's Republic of China, World Health Organization, Shanghai, 200025, China.
Integrated Laboratory of Pathogenic Biology, College of Preclinical Medicine, Dali University, Dali, 671000, People's Republic of China.
出版信息
Sci Rep. 2025 Mar 27;15(1):10637. doi: 10.1038/s41598-025-92939-0.
In this study, we sequenced the complete mitochondrial genome of Theileria velifera and compared it with other Apicomplexan parasites. The mitochondrial genome of T. velifera is a linear monomer molecule spanning 6,125 bp, and it encodes 3 protein-coding genes (PCGs): cox1, cob, and cox3. Besides, it contains 5 large subunit (LSU) rRNA gene fragments and terminal inverted repeats (TIR) at both ends. Moreover, the mitochondrial genomes of most Apicomplexan parasites in this study are typically around 6,000 bp in length and are linear in structure, featuring three PCGs. The start codons observed in Thaleria spp. and Babesia spp. parasites predominantly include ATN, GTN, and TTN, while the end codons are mainly TAA, TAG, and TGA. Phylogenetic analysis showed that T. velifera was closely related to T. annulata, T. parva, T. taurotragi and T. lestoquardi. The complete mitochondrial genome sequence of T. velifera was examined and compared to other Apicomplexan parasites in this study, offering fresh perspectives on the evolution and phylogenetic connections among these parasites.
在本研究中，我们对泰勒虫（Theileria velifera）的完整线粒体基因组进行了测序，并将其与其他顶复门寄生虫进行了比较。泰勒虫的线粒体基因组是一个线性单体分子，长度为6125 bp，编码3个蛋白质编码基因（PCGs）：细胞色素c氧化酶亚基1（cox1）、细胞色素b（cob）和细胞色素c氧化酶亚基3（cox3）。此外，它还包含5个大亚基（LSU）rRNA基因片段以及两端的末端反向重复序列（TIR）。而且，本研究中大多数顶复门寄生虫的线粒体基因组长度通常约为6000 bp，结构为线性，具有3个PCGs。在泰勒虫属（Thaleria spp.）和巴贝斯虫属（Babesia spp.）寄生虫中观察到的起始密码子主要包括ATN、GTN和TTN，而终止密码子主要是TAA、TAG和TGA。系统发育分析表明，泰勒虫与环形泰勒虫（T. annulata）、牛巴贝斯虫（T. parva）、旋角羚泰勒虫（T. taurotragi）和吕氏泰勒虫（T. lestoquardi）密切相关。本研究对泰勒虫的完整线粒体基因组序列进行了检测，并与其他顶复门寄生虫进行了比较，为这些寄生虫之间的进化和系统发育关系提供了新的视角。
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