Gomme Peter T, Bertolini Joseph
Research and Development, CSL Limited, Bioplasma Division, 189-209 Camp Road, Broadmeadows, Victoria 3047, Australia.
Trends Biotechnol. 2004 Jul;22(7):340-5. doi: 10.1016/j.tibtech.2004.05.001.
Vitamin D-binding protein (DBP) is a multi-functional plasma protein with many important functions. These include transport of vitamin D metabolites, control of bone development, binding of fatty acids, sequestration of actin and a range of less-defined roles in modulating immune and inflammatory responses. Exploitation of the unique properties of DBP could enable the development of important therapeutic agents for the treatment of a variety of diseases.
维生素D结合蛋白(DBP)是一种具有多种重要功能的多功能血浆蛋白。这些功能包括维生素D代谢产物的运输、骨骼发育的控制、脂肪酸的结合、肌动蛋白的隔离以及在调节免疫和炎症反应中一系列不太明确的作用。利用DBP的独特特性可以开发出用于治疗多种疾病的重要治疗药物。