Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran 1417613151, Iran.
Department of Mechanical Engineering, Australian College of Kuwait, Safat 13015, Kuwait.
Nutrients. 2021 Sep 16;13(9):3223. doi: 10.3390/nu13093223.
(1) Observational studies have established that vitamin D-binding protein (DBP) and 25-hydroxyvitamin D (25(OH)D) concentrations are the major factors affecting the bioavailability of 25(OH)D. It has also been shown that poor 25(OH)D bioavailability elevates the risk of obesity and its related cardio-metabolic disorders. However, the relationship between 25(OH)D and DBP concentrations with cardio-metabolic risk factors in overweight and obese cohorts has not been established. Consequently, we evaluated the association between DBP and 25(OH)D concentrations with lipid profile, blood pressure (BP), and body composition in overweight and obese women. (2) In this cross-sectional study of 236 overweight and obese women, DBP and 25(OH)D concentrations were measured using an enzyme-linked immunosorbent assay. Body composition was assessed via bioelectrical impedance analysis. Lipid profile and BP were assessed by an auto-analyzer and digital BP monitor, respectively. The associations were examined by multivariate logistic regression. (3) : The indicated showed an inverse relationship between DBP and high-density lipoprotein (HDL) ( = 0.010) concentrations (where individuals with higher DBP had lower HDL) which, after adjusting for possible cofounders, remained significant ( = 0.006). Moreover, DBP concentration was positively associated with fat mass index (FMI) after adjustment ( = 0.022). No significant relationships were observed among 25(OH)D and target variables. (4) : In conclusion, lower concentrations of HDL and higher values of FMI are associated with higher concentrations of DBP in overweight and obese women. These findings present novel awareness regarding the association of DBP with some metabolic and body composition variables in overweight and obese women. However, a two-way causal relationship between DBP and target variables should be considered.
（1）观察性研究已经证实，维生素 D 结合蛋白（DBP）和 25-羟维生素 D（25（OH）D）浓度是影响 25（OH）D 生物利用度的主要因素。此外，已经表明，25（OH）D 生物利用度差会增加肥胖及其相关心血管代谢紊乱的风险。然而，超重和肥胖人群中 25（OH）D 与 DBP 浓度与心血管代谢危险因素之间的关系尚未确定。因此，我们评估了 DBP 和 25（OH）D 浓度与超重和肥胖女性的脂质谱、血压（BP）和身体成分之间的关系。
（2）在这项对 236 名超重和肥胖女性的横断面研究中，使用酶联免疫吸附测定法测量了 DBP 和 25（OH）D 浓度。通过生物电阻抗分析评估身体成分。通过自动分析仪和数字血压监测仪分别评估脂质谱和 BP。通过多元逻辑回归检查关联。
（3）结果表明，DBP 与高密度脂蛋白（HDL）（ = 0.010）浓度呈负相关（即 DBP 较高的个体 HDL 较低），在调整可能的混杂因素后仍具有显著性（ = 0.006）。此外，调整后 DBP 浓度与脂肪质量指数（FMI）呈正相关（ = 0.022）。25（OH）D 与目标变量之间没有观察到显著关系。
（4）结论：在超重和肥胖女性中，较低的 HDL 浓度和较高的 FMI 值与 DBP 浓度较高相关。这些发现提供了关于 DBP 与超重和肥胖女性某些代谢和身体成分变量之间关联的新认识。然而，应该考虑 DBP 和目标变量之间的双向因果关系。
