Li Ling, Han Bing, Kong Yan, Zhang Gaojia, Zhang Zhijun
Research Institution of Neuropsychiatry, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, China.
Department of Neurology, Affiliated Zhongda Hospital, Nanjing, Jiangsu 210009, China.
Genes Dis. 2024 Apr 15;11(5):101309. doi: 10.1016/j.gendis.2024.101309. eCollection 2024 Sep.
Vitamin D binding protein (VDBP) serves as a key transporter protein responsible for binding and delivering vitamin D and its metabolites to target organs. VDBP plays a crucial part in the inflammatory reaction following tissue damage and is engaged in actin degradation. Recent research has shed light on its potential role in various diseases, leading to a growing interest in understanding the implications of VDBP in psychiatric and neurological disorders. The purpose of this review was to provide a summary of the existing understanding regarding the involvement of VDBP in neurological and psychiatric disorders. By examining the intricate interplay between VDBP and these disorders, this review contributes to a deeper understanding of underlying mechanisms and potential therapeutic avenues. Insights gained from the study of VDBP could pave the way for novel strategies in the diagnosis, prognosis, and treatment of psychiatric and neurological disorders.
维生素D结合蛋白(VDBP)是一种关键的转运蛋白,负责将维生素D及其代谢产物结合并输送到靶器官。VDBP在组织损伤后的炎症反应中起关键作用,并参与肌动蛋白降解。最近的研究揭示了其在各种疾病中的潜在作用,这使得人们越来越有兴趣了解VDBP在精神和神经疾病中的影响。本综述的目的是总结目前对VDBP参与神经和精神疾病的认识。通过研究VDBP与这些疾病之间复杂的相互作用,本综述有助于更深入地理解潜在机制和潜在的治疗途径。从VDBP研究中获得的见解可能为精神和神经疾病的诊断、预后和治疗开辟新的策略。