寻找“干性”。
In search of "stemness".
作者信息
Cai Jingli, Weiss Mark L, Rao Mahendra S
机构信息
Gerontology Research Center, Stem Cell Biology Unit/Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
出版信息
Exp Hematol. 2004 Jul;32(7):585-98. doi: 10.1016/j.exphem.2004.03.013.
Stem cells have been identified and characterized in a variety of tissues. In this review we examine possible shared properties of stem cells. We suggest that irrespective of their lineal origin, stem cells have to respond in similar ways to regulate self-renewal and differentiation and it is likely that cell-cycle control, asymmetry/differentiation controls, cellular protective and DNA repair mechanisms, and associated apoptosis/senescence signaling pathways all might be expected to be more highly regulated in stem cells, likely by similar mechanisms. We review the literature to suggest a set of candidate stemness genes that may serve as universal stem cell markers. While we predict many similarities, we also predict that differences will exist between stem cell populations and that when transdifferentiation is considered genes expected to be both similar and different need to be examined.
干细胞已在多种组织中得到鉴定和表征。在本综述中，我们研究了干细胞可能具有的共同特性。我们认为，无论其谱系起源如何，干细胞必须以相似的方式做出反应以调节自我更新和分化，并且细胞周期控制、不对称/分化控制、细胞保护和DNA修复机制以及相关的凋亡/衰老信号通路很可能在干细胞中受到更严格的调控，可能是通过类似的机制。我们回顾文献以提出一组可能作为通用干细胞标志物的候选干性基因。虽然我们预测存在许多相似之处，但我们也预测干细胞群体之间会存在差异，并且在考虑转分化时，需要研究那些预期既相似又不同的基因。
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