磷酸酶与激酶共同参与DNA损伤反应途径。

Phosphatases join kinases in DNA-damage response pathways.

作者信息

Bakkenist Christopher J, Kastan Michael B

机构信息

Department of Hematology and Oncology, St Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA.

出版信息

Trends Cell Biol. 2004 Jul;14(7):339-41. doi: 10.1016/j.tcb.2004.05.001.

DOI:10.1016/j.tcb.2004.05.001

PMID:15246426

Abstract

An inappropriate imbalance of kinase and phosphatase activities could be deleterious to cellular processes such as proliferation. Cellular responses to DNA damage use signal-transduction pathways involving phosphorylation events, and such modifications must be reversible to make these responses transient, rather than permanent, events. Three recent articles describe roles for two phosphatases in signaling pathways that are activated after DNA damage.

摘要

激酶和磷酸酶活性的不适当失衡可能对细胞增殖等细胞过程有害。细胞对DNA损伤的反应利用涉及磷酸化事件的信号转导途径，并且这种修饰必须是可逆的，以使这些反应是短暂的，而非永久性的事件。最近的三篇文章描述了两种磷酸酶在DNA损伤后被激活的信号通路中的作用。