多羟基甾醇的合成（IV）：细胞毒性天然羟基化甾醇24-亚甲基-胆甾-3β,5α,6β,19-四醇的合成
Synthesis of polyhydroxysterols (IV): synthesis of 24-methylene-cholesta-3beta,5alpha,6beta,19-tetrol, a cytotoxic natural hydroxylated sterol.
作者信息
Lu Weigang, Zeng Longmei, Su Jingyu
机构信息
School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China.
出版信息
Steroids. 2004 Jul;69(7):445-9. doi: 10.1016/j.steroids.2004.04.002.
The cytotoxic, polyhydroxylated sterol 24-methylene-cholesta-3beta,5alpha,6beta,19-tetrol (1), previously isolated from the soft corals Nephthea albida and N. tiexieral verseveldt, was synthesized using stigmasterol as the starting material by 10 steps in 9% overall yield. The spectral data and physical constants of 1 were identical with those of the natural product. This is the first report of the synthesis of 1.
细胞毒性的多羟基甾醇24-亚甲基-胆甾-3β,5α,6β,19-四醇（1），先前从软珊瑚Nephthea albida和N. tiexieral verseveldt中分离得到，以豆甾醇为起始原料，经10步反应合成，总产率为9%。1的光谱数据和物理常数与天然产物一致。这是关于1的合成的首次报道。
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