源自海洋真菌青霉属的细胞毒性甾醇
Cytotoxic sterols from marine-derived fungus Pennicillium sp.
作者信息
Sun Yi, Tian Li, Huang Jian, Li Wen, Pei Yue-Hu
机构信息
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
出版信息
Nat Prod Res. 2006 Apr;20(4):381-4. doi: 10.1080/14786410600661229.
A new sterol, ergosta-8(14), 22-diene-3,5,6,7-tetraol(3beta, 5alpha, 6beta, 7alpha, 22E) (1), together with four known sterols ergosta-8(9), 22-diene-3,5,6,7-tetraol (3beta, 5alpha, 6beta, 7alpha, 22E) (2), 5alpha,8alpha-epidioxy-24(S)-methylcholesta-6,22-diene-3beta-ol (3), 5alpha,8alpha-epidioxy-24(S)-methylcholesta-6,9(11), 22-triene-3beta-ol (4), 3beta,5alpha,9alpha-trihydroxyergosta-7,22-diene-6-one (5) was isolated from marine fungus Pennicillium sp. Their structures were determined based on chemical analysis and spectral methods (IR, 1D and 2D NMR, HR-FAB-MS). Compounds 1-5 were evaluated for cytotoxicity against human liver cancer cell (Hep G), and most of them exhibited potent activity. Compound 1 display the highest potency with IC50 values 10.4 microg mL-1.
从海洋真菌青霉属菌株中分离出一种新的甾醇，即麦角甾-8(14),22-二烯-3,5,6,7-四醇(3β,5α,6β,7α,22E)(1)，以及四种已知的甾醇，麦角甾-8(9),22-二烯-3,5,6,7-四醇(3β,5α,6β,7α,22E)(2)、5α,8α-环氧-24(S)-甲基胆甾-6,22-二烯-3β-醇(3)、5α,8α-环氧-24(S)-甲基胆甾-6,9(11),22-三烯-3β-醇(4)、3β,5α,9α-三羟基麦角甾-7,22-二烯-6-酮(5)。通过化学分析和光谱方法(红外光谱、一维和二维核磁共振光谱、高分辨快原子轰击质谱)确定了它们的结构。对化合物1-5进行了针对人肝癌细胞(Hep G)的细胞毒性评估，其中大多数表现出较强的活性。化合物1活性最高，IC50值为10.4μg mL-1。
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