Morikubo Soichi, Takamura Yoshihiro, Kubo Eri, Tsuzuki Shosai, Akagi Yoshio
Division of Ophthalmology, School of Medicine, Fukui University, Fukui, Japan.
Arch Ophthalmol. 2004 Jul;122(7):966-9. doi: 10.1001/archopht.122.7.966.
To evaluate functional impairment in the corneal endothelium of eyes in patients with diabetes mellitus, after small-incision cataract surgery.
Evaluation was performed in 93 eyes in patients with type 2 diabetes mellitus (diabetic group) and 93 eyes in patients without diabetic mellitus (nondiabetic group) who underwent cataract surgery. Using a topography system, the corneal thickness in the central area was measured before surgery and 1 day, 1 week, and 1 month after surgery. Corneal endothelial cells were counted using a noncontact specular microscope.
No significant differences in any preoperative measures were observed between the diabetic and nondiabetic groups. The increase in corneal thickness 1 month after surgery was significantly higher in the diabetic group than in the nondiabetic group (P =.03). The corneal endothelial cell losses 1 day and 1 week after surgery were significantly higher in the diabetic group than in the nondiabetic group (after 1 day, P =.03; and after 1 week, P =.04).
Compared with nondiabetic eyes, eyes of patients with diabetes mellitus showed more damage in corneal endothelial cells due to cataract surgery and a delay in the postoperative recovery of corneal edema.
评估糖尿病患者行小切口白内障手术后角膜内皮的功能损害。
对93例2型糖尿病患者的患眼（糖尿病组）和93例非糖尿病患者的患眼（非糖尿病组）进行白内障手术，并进行评估。使用地形图系统，在手术前以及手术后1天、1周和1个月测量中央区角膜厚度。使用非接触式角膜内皮显微镜对角膜内皮细胞进行计数。
糖尿病组和非糖尿病组术前各项测量指标均无显著差异。糖尿病组术后1个月角膜厚度增加显著高于非糖尿病组（P = 0.03）。糖尿病组术后1天和1周的角膜内皮细胞损失显著高于非糖尿病组（术后1天，P = 0.03；术后1周，P = 0.04）。
与非糖尿病眼相比，糖尿病患者的眼睛因白内障手术导致角膜内皮细胞损伤更严重，且角膜水肿的术后恢复延迟。
