Maár Noémi, Luksch Alexandra, Graebe Alice, Ergun Erdem, Wimpissinger Barbara, Tittl Michael, Vécsei Pia, Stur Michael, Schmetterer Leopold
Department of Ophthalmology, University of Vienna, Vienna, Austria.
Arch Ophthalmol. 2004 Jul;122(7):987-91. doi: 10.1001/archopht.122.7.987.
To investigate the response of retinal vessel diameters to photocoagulation treatment and their role for the success of laser treatment in patients with retinal vein occlusion.
The study included 14 patients with branch vein occlusion or macular vein occlusion. The ophthalmologic examination included best-corrected visual acuity, biomicroscopy, fundus photography, and fluorescein angiography. Retinal vessel diameters were quantified before and after laser photocoagulation using a retinal vessel analyzer.
Retinal vessel diameters.
In cases manifesting macular vein occlusions, no significant change of the vessel diameter in any vessel was observed during the follow-up period. In the group with branch vein occlusion, all vessels tended to constrict after the laser photocoagulation. The effect of laser treatment on retinal vessel diameters was significant for superotemporal (P =.045, analysis of variance [ANOVA]) and inferotemporal branch veins (P =.03, ANOVA). Vasoconstriction was more pronounced in the occluded branch veins (P =.009, ANOVA) compared with the nonaffected veins (P =.12; ANOVA). The change of visual acuity after 3 months was correlated with the change of vessel diameter 3 months after laser treatment for occluded venular branches (r = 0.78, P =.02, linear regression). There was no correlation between the number of laser burns and the change of vessel diameters in the affected veins in this period (r = 0.12, P =.75, linear regression).
Our results show that retinal photocoagulation in patients with branch vein occlusion has a vasoconstrictive effect on occluded veins. The correlation between the change in visual acuity and the change in vessel diameter indicates that branch vein constriction after photocoagulation may be an early indicator of the success of laser treatment.
探讨视网膜静脉阻塞患者视网膜血管直径对光凝治疗的反应及其在激光治疗成功中的作用。
该研究纳入了14例分支静脉阻塞或黄斑静脉阻塞患者。眼科检查包括最佳矫正视力、生物显微镜检查、眼底摄影和荧光素血管造影。使用视网膜血管分析仪在激光光凝前后对视网膜血管直径进行量化。
视网膜血管直径。
在表现为黄斑静脉阻塞的病例中，随访期间任何血管的直径均未观察到显著变化。在分支静脉阻塞组中，激光光凝后所有血管均有收缩趋势。激光治疗对视网膜血管直径的影响在颞上（P = 0.０45，方差分析[ANOVA]）和颞下分支静脉（P =０.０3，ANOVA）方面具有统计学意义。与未受影响的静脉相比（P =０.12；ANOVA），阻塞分支静脉的血管收缩更为明显（P =０.009，ANOVA）。激光治疗3个月后视力的变化与阻塞静脉分支激光治疗3个月后血管直径的变化相关（r = 0.78，P =０.02，线性回归）。在此期间，激光光斑数量与受影响静脉血管直径的变化之间无相关性（r = 0.12，P =０.75，线性回归）。
我们的结果表明，分支静脉阻塞患者的视网膜光凝对阻塞静脉有血管收缩作用。视力变化与血管直径变化之间的相关性表明，光凝后分支静脉收缩可能是激光治疗成功的早期指标。
