Marra Maurizio, Scalfi Luca, Contaldo Franco, Pasanisi Fabrizio
Inter-University Center for Obesity and Eating Disorders (CISRO), Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy.
Ann Nutr Metab. 2004;48(3):189-92. doi: 10.1159/000079556. Epub 2004 Jul 6.
BACKGROUND/AIMS: The identification of metabolic and environmental predictors of excess body fat is still far from being achieved. The aim of this study was to evaluate whether respiratory quotient in non-obese women is a predictor of body weight changes after a 6-year follow-up period.
Forty-three non-obese healthy women participated in the study. Their baseline general characteristics were: age 40.5 +/- 12.8 years; height 159 +/- 7 cm; weight 61.8 +/- 10.1 kg, and body mass index (BMI) 24.4 +/- 3.8 kg/m2. At baseline basal metabolic rate and respiratory quotient were determined by indirect calorimetry, while weight and BMI were recorded at the first observation and after the 3- and 6-year follow-ups.
At the first observation basal metabolic rate was 5,360 +/- 713 kJ/day and respiratory quotient 0.850 +/- 0.052. After 6 years, with weight changes equal to 1.4 +/- 4.5 kg, baseline respiratory quotient was a significant predictor (p < 0.05) of changes in body weight or BMI together with baseline BMI.
This follow-up study confirms that a high respiratory quotient (measured on free diet) predisposes to weight gain, especially in women with the highest baseline respiratory quotient (above the 90th percentile of the distribution for this variable).
背景/目的：识别身体脂肪过多的代谢和环境预测因素仍远未实现。本研究的目的是评估非肥胖女性的呼吸商是否是6年随访期后体重变化的预测指标。
43名非肥胖健康女性参与了本研究。她们的基线一般特征为：年龄40.5±12.8岁；身高159±7厘米；体重61.8±10.1千克，体重指数（BMI）24.4±3.8千克/平方米。在基线时，通过间接测热法测定基础代谢率和呼吸商，同时在首次观察时以及3年和6年随访后记录体重和BMI。
在首次观察时，基础代谢率为5360±713千焦/天，呼吸商为0.850±0.052。6年后，体重变化为1.4±4.5千克，基线呼吸商与基线BMI一起是体重或BMI变化的显著预测指标（p<0.05）。
这项随访研究证实，高呼吸商（在自由饮食状态下测量）易导致体重增加，尤其是基线呼吸商最高的女性（高于该变量分布的第90百分位数）。
