抑制白细胞介素-6用于治疗炎症性疾病。

Inhibition of IL-6 for the treatment of inflammatory diseases.

作者信息

Nishimoto Norihiro, Kishimoto Tadamitsu

机构信息

Laboratory of Immune Regulation, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamada-oka, Suita-City, Osaka, 565-0871, Japan.

出版信息

Curr Opin Pharmacol. 2004 Aug;4(4):386-91. doi: 10.1016/j.coph.2004.03.005.

DOI:10.1016/j.coph.2004.03.005

PMID:15251133

Abstract

Interleukin-6 (IL-6) is a pleiotropic cytokine with various biological activities. Deregulated overproduction of IL-6 has been found to play pathological roles in chronic inflammatory diseases such as rheumatoid arthritis, Castleman's disease, juvenile idiopathic arthritis and Crohn's disease. Humanized anti-IL-6 receptor antibody has been developed as a therapeutic agent for these diseases, and therapeutic benefits have been revealed in clinical studies.

摘要

白细胞介素-6（IL-6）是一种具有多种生物学活性的多效性细胞因子。已发现IL-6的过量产生失调在类风湿性关节炎、卡斯尔曼病、幼年特发性关节炎和克罗恩病等慢性炎症性疾病中发挥病理作用。人源化抗IL-6受体抗体已被开发为这些疾病的治疗药物，并且临床研究已揭示了其治疗益处。