Laboratory of Immune Regulation, Wakayama Medical University, Ibaraki-City, Japan.
Clin Pharmacol Ther. 2010 Apr;87(4):483-7. doi: 10.1038/clpt.2009.313. Epub 2010 Feb 24.
Interleukin (IL)-6 is a multifunctional cytokine that regulates immune response, inflammation, and hematopoiesis. Although IL-6 plays several important physiological roles, deregulated overproduction of IL-6 causes various clinical symptoms and abnormalities in laboratory test results. Overproduction of IL-6 has been shown to underlie a number of autoimmune and inflammatory diseases, including rheumatoid arthritis (RA), systemic-onset juvenile idiopathic arthritis (soJIA), and Castleman's disease, as well as malignancies such as multiple myeloma and mesothelioma. Blocking of IL-6 signaling may be therapeutic in diseases characterized by pathological IL-6 overproduction. This review provides an overview of IL-6 as a therapeutic target in candidate inflammatory diseases.
白细胞介素 (IL)-6 是一种多功能细胞因子，可调节免疫反应、炎症和造血。虽然 IL-6 发挥了多种重要的生理作用，但过度产生 IL-6 会导致各种临床症状和实验室检查结果异常。研究表明，IL-6 的过度产生与多种自身免疫性和炎症性疾病有关，包括类风湿关节炎 (RA)、全身型幼年特发性关节炎 (soJIA) 和 Castleman 病，以及多发性骨髓瘤和间皮瘤等恶性肿瘤。阻断 IL-6 信号可能对病理性 IL-6 过度产生的疾病具有治疗作用。本文综述了 IL-6 作为候选炎症性疾病治疗靶点的相关内容。
