甲下（杜普伊特伦氏）外生骨疣和奇异的骨旁骨软骨瘤性增殖（诺拉病变）中的独特染色体重排。
Distinct chromosomal rearrangements in subungual (Dupuytren) exostosis and bizarre parosteal osteochondromatous proliferation (Nora lesion).
作者信息
Zambrano Eduardo, Nosé Vânia, Perez-Atayde Antonio R, Gebhardt Mark, Hresko M Timothy, Kleinman Paul, Richkind Kathleen E, Kozakewich Harry P W
机构信息
Department of Pathology, Children's Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
出版信息
Am J Surg Pathol. 2004 Aug;28(8):1033-9. doi: 10.1097/01.pas.0000126642.61690.d6.
BACKGROUND
Proliferative lesions of the bone surface, such as subungual (Dupuytren) exostosis and bizarre parosteal osteochondromatous proliferation (BPOP, Nora lesion) are currently classified as reactive, proliferative processes that mimic primary neoplasms of bone.
METHODS
Cytogenetic analysis was performed on 3 subungual exostoses of the great toe and 2 BPOP lesions of the radius and ulna.
RESULTS
A balanced translocation t(X;6) was identified in all cases of subungual exostoses. The chromosomal rearrangements observed in 1 case of BPOP differed from those seen in subungual exostosis.
CONCLUSIONS
The presence of chromosomal abnormalities in subungual exostosis and BPOP suggests that these lesions are neoplastic, with a different molecular pathogenesis, and that each is a distinct clinicopathologic entity.
背景
骨表面的增殖性病变，如甲下（杜普伊特伦）外生骨疣和奇异的骨旁骨软骨瘤样增殖（BPOP，诺拉病变），目前被归类为模仿原发性骨肿瘤的反应性、增殖性过程。
方法
对3例大脚趾甲下外生骨疣和2例桡骨及尺骨BPOP病变进行了细胞遗传学分析。
结果
在所有甲下外生骨疣病例中均发现了平衡易位t(X;6)。1例BPOP中观察到的染色体重排与甲下外生骨疣不同。
结论
甲下外生骨疣和BPOP中存在染色体异常表明这些病变是肿瘤性的，具有不同的分子发病机制，且每种都是独特的临床病理实体。
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