一种用于基于Fmoc的固相肽合成的新型环境敏感型荧光氨基酸。
A new environment-sensitive fluorescent amino acid for Fmoc-based solid phase peptide synthesis.
作者信息
Eugenio Vazquez M, Rothman Deborah M, Imperiali Barbara
机构信息
Departments of Chemistry and Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
出版信息
Org Biomol Chem. 2004 Jul 21;2(14):1965-6. doi: 10.1039/b408001g. Epub 2004 Jun 22.
DOI:10.1039/b408001g
PMID:15254619
Abstract
A new 4-(N,N-dimethylamino) phthalimide-based environment-sensitive fluorescent building block for solid phase peptide synthesis, has been synthesized and incorporated into peptides. Peptides incorporating this residue show great potential for biological applications in sensing protein/protein interactions.
摘要
一种用于固相肽合成的新型基于4-(N,N-二甲基氨基)邻苯二甲酰亚胺的环境敏感型荧光构建块已被合成并掺入肽中。含有该残基的肽在传感蛋白质/蛋白质相互作用的生物学应用中显示出巨大潜力。
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